Community care system design and development with AUML

An approach to the development of an appropriate agent environment is described in which software researchers collaborate with environment builders to enhance the levels of cooperation and support provided within an integrated agent-oriented community system. Agent-oriented Unified Modelling Language (AUML) is a practical approach to the analysis, design, implementation and management of such a software agent system, whilst providing the power and expressiveness necessary to support the specification, design and organisation of a health care service. This paper describes the background of agent-based health care and the fundamental concepts of Agentoriented UML and outlines how this refreshing approach can be used in the analysis, design, development and organization of agent-based community health care systems. Our approach to building agent-oriented software development solutions emphasizes the importance of AUML as a fundamental initial step in producing agent-based architectures and applications. This approach aims to present an effective schedule and methodology for an agent software development process, by addressing the complex agent environments decomposition, abstraction, organization and software development process activities characteristics, whilst reducing the complexity of the complex agent systems' design and development by using and exploiting AUML's productivity potential

An agent-based architecture for managing the provision of community care: the INCA (Intelligent Community Alarm) experience

Community care is an area that requires extensive ooperation between independent agencies, each of which needs to meet its own objectives and targets. None are engaged solely in the delivery of community care, and need to integrate the service with their other responsibilities in a coherent and efficient manner. Agent technology provides the means by which effective cooperation can take place without compromising the essential security of both the client and the agencies involved as the appropriate set of responses can be generated through negotiation between the parties without the need for access to the main information repositories that would be necessary with conventional collaboration models. The autonomous nature of agents also means that a variety of agents can cooperate together with various local capabilities, so long as they conform to the relevant messaging requirements. This allows a variety of agents, with capabilities tailored to the carers to which they are attached to be developed so that cost-effective solutions can be provided

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels

Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently identified schizophrenia risk factor phosphodiesterase-4B (PDE4B). Here we report that the 100 kDa full-length DISC1 isoform (fl-DISC1) can bind members of each of the four gene, cAMP-specific PDE4 family. Elevation of intracellular cAMP levels, so as to activate protein kinase A, caused the release of PDE4D3 and PDE4C2 isoforms from fl-DISC1 while not affecting binding of PDE4B1 and PDE4A5 isoforms. Using a peptide array strategy, we show that PDE4D3 binds fl-DISC1 through two regions found in common with PDE4B isoforms, the interaction of which is supplemented because of the presence of additional PDE4B-specific binding sites. We propose that the additional binding sites found in PDE4B1 underpin its resistance to release during cAMP elevation. We identify, for the first time, a functional distinction between the 100 kDa long DISC1 isoform and the short 71 kDa isoform. Thus, changes in the expression pattern of DISC1 and PDE4 isoforms offers a means to reprogram their interaction and to determine whether the PDE4 sequestered by DISC1 is released after cAMP elevation. The PDE4B-specific binding sites encompass point mutations in mouse Disc1 that confer phenotypes related to schizophrenia and depression and that affect binding to PDE4B. Thus, genetic variation in DISC1 and PDE4 that influence either isoform expression or docking site functioning may directly affect psychopathology

Folie a Famille Associated with Amphetamine Use

Shared Psychotic Disorder involving an entire family (folie a famille) is extremely rare. Only two cases of Shared Psychotic Disorder linked to stimulant abuse have been documented in the literature. We report a case of folie a famille that involved 5 members of a family, and was associated with amphetamine use in the primary individual. Our case shares many clinical and etilogical factors with previously reported cases of shared psychotic disorders. A wide variety of psychotic manifestations are associated with amphetamine use and clinicians should be aware of this uncommon syndrome among stimulant-using population, particularly due to the recent increase in methamphetamine use and the link between delusional disorders and violence among these individuals

Not all risks are equal: The risk taking inventory for high-risk sports

Although high-risk sport participants are typically considered a homogenous risk-taking population, attitudes to risk within the high-risk domain can vary considerably. As no validated measure allows researchers to assess risk taking within this domain, we validated the Risk Taking Inventory (RTI) for high-risk sport across four studies. The RTI comprises seven items across two factors: deliberate risk taking and precautionary behaviors. In Study 1 (n = 341), the inventory was refined and tested via a confirmatory factor analysis used in an exploratory fashion. The subsequent three studies confirmed the RTI's good model-data fit via three further separate confirmatory factor analyses. In Study 2 (n = 518) and in Study 3 (n = 290), concurrent validity was also confirmed via associations with other related traits (sensation seeking, behavioral activation, behavioral inhibition, impulsivity, self-esteem, extraversion, and conscientiousness). In Study 4 (n = 365), predictive validity was confirmed via associations with mean accidents and mean close calls in the high-risk domain. Finally, in Study 4, the self-report version of the inventory was significantly associated with an informant version of the inventory. The measure will allow researchers and practitioners to investigate risk taking as a variable that is conceptually distinct from participation in a high-risk spor

Constructing Gravitational Dimensions

It would be extremely useful to know whether a particular low energy effective theory might have come from a compactification of a higher dimensional space. Here, this problem is approached from the ground up by considering theories with multiple interacting massive gravitons. It is actually very difficult to construct discrete gravitational dimensions which have a local continuum limit. In fact, any model with only nearest neighbor interactions is doomed. If we could find a non-linear extension for the Fierz-Pauli Lagrangian for a graviton of mass mg which does not break down until the scale Lambda_2=(mg Mpl)^(1/2), this could be used to construct a large class of models whose continuum limit is local in the extra dimension. But this is shown to be impossible: a theory with a single graviton must break down by Lambda_3 = (mg^2 Mpl)^(1/3). Next, we look at how the discretization prescribed by the truncation of the KK tower of an honest extra diemsinon rasies the scale of strong coupling. It dictates an intricate set of interactions among various fields which conspire to soften the strongest scattering amplitudes and allow for a local continuum limit. A number of canditate symmetries associated with locality in the discretized dimension are also discussed.Comment: 21 pages, 6 diagrams, 1 figur

Discrete Gravitational Dimensions

We study the physics of a single discrete gravitational extra dimension using the effective field theory for massive gravitons. We first consider a minimal discretization with 4D gravitons on the sites and nearest neighbor hopping terms. At the linear level, 5D continuum physics is recovered correctly, but at the non-linear level the theory becomes highly non-local in the discrete dimension. There is a peculiar UV/IR connection, where the scale of strong interactions at high energies is related to the radius of the dimension. These new effects formally vanish in the limit of zero lattice spacing, but do not do so quickly enough to reproduce the continuum physics consistently in an effective field theory up to the 5D Planck scale. Nevertheless, this model does make sense as an effective theory up to energies parametrically higher than the compactification scale. In order to have a discrete theory that appears local in the continuum limit, the lattice action must have interactions between distant sites. We speculate on the relevance of these observations to the construction of finite discrete theories of gravity in four dimensions.Comment: 5 pages, 4 diagrams. Important typos in some equations corrected; conclusion s unchange